Sudden Death due to Glioblastoma NOS: A Rare Medicolegal Autopsy Case Report in Indian Scenario
DOI:
https://doi.org/10.48165/Keywords:
Autopsy, Glioblastoma, Histopathology, Sudden deathAbstract
Even though the era has grown up into tremendous technological advances in health care, diagnosis of sudden death is still challenging. The definition of sudden death predominantly depends upon the duration and onset of symptoms. According to the World Health Organization (WHO) and International Classification of Diseases, version 10 (ICD-10) sudden death is non-violent and not otherwise explained, occurring less than 24 hours from the onset of symptoms.' There are several studies across the world that give ideas about patterns and profiles of cases of sudden death in relation to different age groups. As mentioned in one of the studies, sudden deaths due to an undiagnosed primary intracranial neoplasm are exceptionally rare ones, with reported frequencies in the range of 0.02% to 2.1% in medico-legal autopsy series. Out of which, only 12% of all cases of sudden, unexpected death due to primary intracranial tumors are due to Glioblastomas." The present case report describes the autopsy diagnosis of Glioblastoma NOS (Not Other wise Specified) in a case of sudden and unexplained death of a 40-year-old apparently healthy male.
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References
Nofal HK, Abdulmohsen MF, Khamis AH. Incidence and causes of sudden death in a university hospital in eastern Saudi Arabia. Eastern Mediterranean Health Journal; Vol. 17(9). 2011.
Di Maio VJM, Di Maio DJ. Forensic pathology, 2nd Ed.
London. CRC Press. 2001.
International classification of diseases (ICD-10). Geneva,
World Health Organization;2005.
Sung RJ. Kuo Chi-Tai, Wa Shan-Nan, Lai WT, Luqman N, and Chan NY. Sudden cardiac death syndrome: age, gender, ethnicity, and genetics. Acta CardiologicaSinica; 2008. 24:65-74.
Spiliopoulou C et al. Clinical diagnoses and autopsy findings: a retrospective analysis of 252 cases in Greece. Archives of Pathology & Laboratory Medicine. 2005.
Morentin B et al. Incidencia y causas de muertesubitaenmenores de 36 anos [Incidence and causes of sudden death in persons less than 36 years of age]. Medicina Clínica; 2001. 116:294-295.
Kojima M et al. Sudden death of clinically unknown origin. An overview of post-mortem examinations in Japan. Japanese Journal of Public Health; 1999. 46:563-568.
Nashelsky MB, Lawrence CH. Accuracy of the cause of
death determination without forensic autopsy examination. American Journal of Forensic Medicine and Pathology; 2003. 24:313-319.
Blackwell CC et al. Sudden unexpected nocturnal deaths among Thai immigrant workers in Singapore. The possible role of toxigenic bacteria. International Journal of Legal Medicine; 1994. 106:205-208.
Eckart RE et al. Sudden death in young adults: a 25-year review of autopsies in military recruits. Annals of Internal Medicine; 2004. 141(11):829-834.
Irene Riezzo et al. Sudden, unexpected death due to glioblastoma: report of three fatal cases and review of the literature. Diagnostic Pathology; 2013. 8:73.
The National Cancer Institute, SEER, Bethesda. 2019. Available from: URL: https://seer.cancer.gov /statfacts/html/brain.html.
Matschke J. Primary cerebral neoplasm as a cause of sudden, unexpected death. Forensic Pathology Reviews Vol. 2.
Edited by Michael Tsokos. 2005:46-50.
Vougiouklakis T, Mitselou A, Agnantis NJ. Sudden death due to primary intracranial neoplasms. A forensic autopsy study. Anticancer Res. 2006. May-Jun; 26(3B):2463-6.
Louis, D.N., Perry, A., Reifenberger, G. et al. The 2016 world health organization classification of tumors of the central nervous system: a summary. Acta;Neuropathol:2016. 131:803–820.
Matschke J, Tsokos M. Sudden unexpected death due to undiagnosed glioblastoma: report of three cases and review of the literature. Int J Legal Med. 2005;119(5):280–284. 17. Black M, Graham DI. Sudden unexplained death in adults caused by intracranial pathology. J Clin Pathol. 2002;55(1):44-50.
Riezzo I, Zamparese R, Neri M, et al. Sudden, unexpected death due to glioblastoma: report of three fatal cases and review of the literature. DiagnPathol. 2013;8:73.
Manousaki M, Papadaki H, Papavdi A, et al. Sudden unexpected death from oligodendroglioma: a case report and review of the literature. Am J Forensic Med Pathol. 2011;32(4):336–340.
Sutton JT, Cummings PM, Ross GW, Lopes MB. Sudden death of a 7-year-old boy due to undiagnosed glioblastoma. Am J Forensic Med Pathol. 2010;31(3):278–280.
Vyshka G, Shaqiri E, Ymaj B. Sudden death due to medulloblastoma. BMJ Case Rep.2010;2010:bcr10.2009. 2378. doi:10.1136/bcr.10.2009.2378.
