Challenges in Estimation of Post Mortem Interval from Vitreous Potassium Concentration in Global Perspective: A Systematic Review
DOI:
https://doi.org/10.48165/jiafm.2023.45.3.10Keywords:
Forensic science, Forensic patholog, Postmortem changes, PotassiumAbstract
Postmortem interval as an essential component of death investigation needs to be precisely estimated scientifically as far as practicable. In decomposed bodies, vitreous humour potassium concentration holds scientific merit as they resist early bacterial putrefaction. However, the quantitative estimation of ion depends on several factors, such as climatic, seasonal, storage conditions apart from biological age and hidden pathological condition of the deceased concerned. Thus equations formulated in a particular climatic condition may not be validated with other. Some of the studies generated regression equations based on their regional climatic considerations, but they highly vary with other studies performed across the geographic barrier. Global studies suggested immediate freezing of samples below -20°C to maintain its quality for forensic analysis. Samples should not be exposed to light and temperature. The immediate challenges in the field are explored and outlined comprehensively and possible solutions to the feasible context are recommended.
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References
Murthy AS, Das S, Thazhath HK, Chaudhari VA, Adole PS. The effect of cold chamber temperature on the cadaver's electrolyte changes in vitreous humor and plasma. Journal of Forensic and Legal Medicine. 2019 Feb 1;62:87-91.
Taware Ajay A, Tatiya Harish S, Jadhav Vijay T, Punpale SB. Correlation between Vitreous Electrolytes and Time since Death: An Autopsy Based Study. Indian Journal of Forensic Medicine and Pathology. 2017 Apr;10(2):122.
Li W, Chang Y, Cheng Z, Ling J, Han L, Li X, Ding Y. Vitreous humor: A review of biochemical constituents in postmortem interval estimation. Journal of Forensic Science and Medicine. 2018 Apr 1;4(2):85.
Ave MT, Ordóñez-Mayán L, Camiña M, Febrero-Bande M, Muñoz-Barús JI. Estimation of the post-mortem interval: Effect of storage conditions on the determination of vitreous humour [K+]. Science & Justice. 2021 Sep 1;61(5):597-602.
Mohamed Nasim R. Prospective Analysis of Electrolytic Changes in Vitreous Humour regarding Estimation of Time Since Death (Doctoral dissertation, Madurai Medical College, Madurai).
SM R. Role of Vitreous Humor in Estimating Time Since Death. Indian Journal of Forensic Medicine & Toxicology. 2019 Apr 1;13(2).
Shrivastava A, Sharma N, Vaishnawa N, Vyas PC. Estimation of Post-Mortem Interval from the Changes in Vitreous Humour Potassium (K) and Sodium (Na) Level.
Singh G, Sharma DK, Pathak D, Dutta S. Comparative Study on Post Mortem Analysis of Sodium and Potassium Levels of Vitreous Humour and Synovial Fluid in Determining Time Since Death. Indian Journal of Forensic Medicine & Toxicology. 2022 Jul 4;16(3):393-8.
Paul PM, Sneha S, Pradhan P, Kumar PS. Estimation of post mortem interval from vitreous potassium: An autopsy based
study. Journal of Indian Academy of Forensic Medicine. 2021;43(4):370-3.
Angayarkanni S. Analysis of vitreous humour in determining postmortem interval (time since death)–Aprospective study. IP International Journal of Forensic Medicine and Toxicological Sciences. 2021 Jan 15;5(4):121-9.
Dhuvarkesh A. Electrolyte composition of Vitreous humour and Cerebrospinal fluid as a tool todetermine the Post Mortem Interval (Doctoral dissertation, Coimbatore Medical College, Coimbatore).
Nasim RM, Selvaraj T. Prospective Anaylysis of Electrolytic Changes in Vitreous Humour Regarding Estimation of Time Since Death. Prof. RK Sharma. 2019 Jan;13(1):177.
Rama V. Assessing time since death by using changes in electrolytes in CSF and vitreous humour in bodies subjected to autopsy (Doctoral dissertation, Tirunelveli Medical College, Tirunelveli).
Tatiya HS, Taware AA, Jadhav VT, Punpale SB. Between Eye Difference in Vitreous Electrolytes after Death; for Identical Postmortme Intervals. Indian Journal of Forensic Medicine & Toxicology. 2017 Jul 1;11(2).
Ioelu L, Garland J, Palmiere C, Ondruschka B, Da Broi U, Glenn C, et al. Use of vitreous humor electrolytes in estimating postmortem interval in infant population (< 1 year). Australian Journal of Forensic Sciences. 2021 Jul 26:1-0.
Palacio C, Gottardo R, Cirielli V, Musile G, Agard Y, Bortolotti F, et al. Simultaneous analysis of potassium and ammonium ions in the vitreous humour by capillary electrophoresis and their integrated use to infer the post mortem interval (PMI). Medicine, Science and the Law. 2021 Jan;61(1_suppl):96-104.
Focardi M, Lanzilao L, Bonari A, Lazzeretti M, Lorubbio M, Ognibene A, et al. Improvement in estimation of time since death by albumin and potassium concentrations in vitreous
ISSN : 0971 - 0973, e - ISSN : 0974 - 0848
humor. Forensic Science International. 2020 Sep 1;314:110393.
Garland J, Olds K, Rousseau G, Palmiere C, Ondruschka B, Kesha K, et al. Using vitreous humour and cerebrospinal fluid electrolytes in estimating post-mortem interval-an exploratory study. Australian Journal of Forensic Sciences. 2020 Nov 1;52(6):626-33.
Garland J, Philcox W, McCarthy S, Kesha K, Lam L, Spark A, et al. Post-mortem biochemistry differences between vitreous humour and cerebrospinal fluid. Australian Journal of Forensic Sciences. 2020 Sep 2;52(5):518-28.
Pérez-Martínez C, Prieto Bonete G, Pérez-Cárceles MD, Luna A. Influence of the nature of death in biochemical analysis of the vitreous humour for the estimation of post mortem interval. Australian Journal of Forensic Sciences. 2020 Sep 2;52(5):508-17.
Risoluti R, Canepari S, Frati P, Fineschi V, Materazzi S. “2 n Analytical Platform” To Update Procedures in Thanatochemistry: Estimation of Post Mortem Interval in Vitreous Humor. Analytical chemistry. 2019 May 6;91(11):7025-31.
Cordeiro C, Ordóñez-Mayán L, Lendoiro E, Febrero-Bande M, Vieira DN, Muñoz-Barús JI. A reliable method for estimating the postmortem interval from the biochemistry of the vitreous humor, temperature and body weight. Forensic science international. 2019 Feb 1;295:157-68.
Agoro ES, Okoye FB, Onyenekwe CC, Azuonwu O, Ebiere NE. Extrapolation of three hourly post-mortem interval using some vitreous chemistry parameters. J Forensic Res. 2017;8(1):360.
Prieto-Bonete G, Legaz I, Pérez-Martínez C, Pérez-Cárceles MD, Luna A. Biochemical correction factors to estimation of post-mortem interval in vitreous humor. Rom J Leg Med. 2017 Jun 1;25:201-4.
