The Study of CNS Manifestations in Aluminium Phosphide Poisoning
DOI:
https://doi.org/10.48165/Keywords:
Aluminium Phosphide Poisoning, CNS Manifestations, Sensorium of the PatientAbstract
With rapid development in the field of science & technology and green revolution in the agricultural sector, the problem of acute aluminium phosphide poisoning leading to morbidity and mortality is spreading like a wild fire. Different disciplines of medical science are working on various aspects both from treatment as well as preventive point of view. Aluminium Phosphide is a very toxic, cheap, ideal suicidal and lethal protoplasmic poison involving all generations and organ systems of the body. Although its incidence was unknown before 1980 but now it has surpassed every other poisoning in India especially in the northern states and has created havoc with the human lives. Our study showed that males (1.94:1) are the major sufferer with high mortality rate (76%). The freshness of tablet and lack of specific antidote are directly related to its poor prognosis. Major CNS manifestations are dizziness (52%) and headache (44%). Loss of consciousness is only the terminal event and sufficient time is available to record the dying declaration. Magnesium sulphate has some role in its management.
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References
Vij K. Forensic Toxicology. Textbook of Forensic Medicine and Toxicology. VIth ed. Elsevier- A division of Reed Elsevier India Private Limited; New Delhi 2014:505-509.
Khurana P, Dalal JS, Multani AS, Tejpal HR, Gupta A. The study of respiratory and abdominal manifestations in aluminium phosphide
poisoning. J Punjab Acad Forensic Med Toxicology 2012; 12(1):25- 28.
Khurana P, Dalal JS, Multani AS, Tejpal HR. The study aluminium phosphide poisoning in a tertiary care hospital, Amritsar. JIAFM. Oct-Dec 2011; 33(4):332-336.
Reddy KSN. Toxicology. The Essentials of Forensic Medicine and Toxicology. 25th Ed. K. Suguna Devi, Malakpet; Hyderabad 2005:445-447.
Nakakita H,Katsumata Y, Ozawa T. The effect of phosphine on the respiration of rat liver mitochondria. J Biochem 1971;68:589-593. 6. Prince NR, Dance SJ. Some biochemical aspects of phosphine action and resistance in three species of stored product beetles. Comp. Biochem Physiol 1983;76:277-281.
Cheuferka W, Kashi KP, Bond EJ. The effect of phosphine electrone transport in mitochondria. Pestic Biochem Physio 1976;6:65-84.
Chugh SN. Aluminium phosphide poisoning. Journal of Association of Physician of India 1992; 40(6):401-405.
Chugh SN, Santram, Chugh K, Malhotra KC. Spot diagnosis of aluminium phosphide ingestion: An application of a simple test. Journal of Association of Physician of India 1989; 37 (3): 219 – 220.
Mital HS, Mehrotra TN, Dwivedi KK, Gera M. A study of aluminium phosphide poisoning with special reference to its spot diagnosis by silver nitrate test. Journal of Association of Physician of India 1992; 40(7): 473-474.
Kalra GS, Anand IS, Jit I, Bushnurmath B, Wahi PL. Aluminium phosphide poisoning: Haemodynamic observations. Indian Heart Journal 1991; 43(3):175-178.
Chopra JS, Kalra OP, Malik VS, Sharma R, Chandna A. Aluminium phosphide poisoning: A prospective study of 16 cases in one year. Postgraduate Medical Journal 1986; 62:1113-1115.
Gupta MS, Malik A, Sharma VK. Cardiovascular manifestations in aluminium phosphide poisoning with special reference to echocardiographic changes. Journal of Association of Physician of India 1995; 43(11):773-780.
Khosla SN. Cardiovascular manifestations of aluminium phosphide poisoning. Journal of association of physician of India 1990; 38(6):443-444.
Chugh SN, Pal R, Singh V, Seth S. Serial blood phosphine levels in acute aluminium phosphide poisoning. Journal of Association of Physician of India 1996; 44 (3):184-185.
Chugh SN, Kumar P, Aggarwal HK, Sharma A, Mahajan SK, Malhotra KC. Efficacy of magnesium sulphate in aluminium phosphide poisoning comparison of two different dose schedules. Journal of association of physician of India 1994; 42(5):373-375.
Siwach SB, Dua A, Sharma R, Sharma D, Mehla RK. Tissue magnesium content and histopathological changes in non- survivors of aluminium phosphide poisoning. Journal of Association of Physician of India 1995; 43(10):676-678.