Estimation of Time Passed Since Death by New Biochemical Parameters: MDA (Malondialdehyde) and Total Thiol

Authors

  • Sanchita Das Kundu Assistant Professor, Department of Forensic & State Medicine, Nil Ratan Sircar Medical College and Hospital, Kolkata, West Bengal
  • Apurba Biswas Assist. Prof, Dept. of Forensic & State Medicine, Maldah Medical College and Hospital, Maldah, WB
  • Abhishek Das 3Final year PGT, Dept. of Forensic & State Medicine, NRSMCH, Kolkata, West Bengal
  • Anindya Kumar Goswami Assist. Prof, Final year PGT, Dept. of Forensic & State Medicine, NRSMCH, Kolkata, West Bengal
  • Parvind Kumar Singh Assist. Prof, Dept. of Forensic & State Medicine, Sagar Dutta Medical College and Hospital, WB
  • Prabhas Chandra Chakraborty Prof & HOD, NRSMCH Kolkata, West Bengal

DOI:

https://doi.org/10.48165/

Keywords:

Time passed since death, Biochemical parameters, MDA, Total Thiol, Causes of death

Abstract

Determination of time passed since death is extremely important medico-legal issue. It requires  meticulous examination, documentation and subsequent necessary evaluation by various pathological  and biochemical examination. Two biochemical parameters, MDA breakdown product of lipid per  oxidation and Total Thiol which is responsible for the protection of cells against oxidative stress are  measured to estimate Time Passed since Death. Pearson correlation in various causes of death shows  MDA level is significantly correlated with time passed since death, whereas Total Thiol level is inversely  proportional. This study establishes role of MDA and Total Thiol as biochemical parameters to estimate  time passed since death. 

Downloads

Download data is not yet available.

References

Jetter WW, McLean R. Biochemical changes in body fluids after death. Am.J.Clin.Pathol, 13:178, 1943

Brown KM, Morrice PC, Duthie GG. Vitamin E suppresses indexes of lipid peroxidation and platelet count in blood of smokers and nonsmokers but plasma lipoprotein concentrations remain unchanged. Am. J Clin Nutr 1994; 60: 383-387.

Del Rio D. A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis. 2005 Aug; 15(4):316-28.

Flemming Nielsen. Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors, Clinical Chemistry. 1997; 43:1209-1214

P. Catomeris et al. Lipid peroxidation in postmortem blood of fire victims Micro chemical Journal 41( 3), June 1990, Pages 271-277. 6. Mukherjee J B. Death and its Medicolegal Aspects. Forensic Medicine and Toxicology. Edited by R N Karmakar. Academic Publishers. 3rd Ed. 2007.314-316.

Knight Bernard. Changes after Death. The Estimation of the Time since Death in the Early Postmortem Period. Arnold Publishers.2nd ed.225-229.

Reddy K S N. Postmortem Changes.The Essentials of Forensic Medicine and Toxicology. K. Suguna Devi Publishers. Thirtieth Edition.2011.161.

Evans W.E.D. The Chemistry of death.Springfield, 1ll., Charles C Thomas,1963

Published

2014-04-30

How to Cite

Kundu, S. D., Biswas, A., Das, A., Goswami, A. K., Singh, P. K., & Chakraborty , P. C. (2014). Estimation of Time Passed Since Death by New Biochemical Parameters: MDA (Malondialdehyde) and Total Thiol . Journal of Indian Academy of Forensic Medicine, 36(1), 38-39. https://doi.org/10.48165/