Alprazolam Poisoning
DOI:
https://doi.org/10.48165/Keywords:
Abuse, Availability, Psychotic, Triggering, SuicideAbstract
Alprazolam is a triazolo benzodiazepine which has antidepressant properties. It is a short acting anxiolytic of the benzodiazepine class of psychoactive drugs. Alprazolam like other benzodiazepines binds to specific sites on the gamma-amino-butyric acid (GABA) receptors. Its therapeutic index being high, it is generally considered a safe and effective drug for the treatment of anxiety disorders and panic attack. Alprazolam has since long been consumed as drug of abuse, however trend to use it for suicidal purpose is recently rising, in which easy availability of this drug plays a significant role. It is available for oral administration in compressed tablet and extended release capsule formulations. We report one such case of alprazolam poisoning in which the drug was easily available. As is evident from this report documentation, inability to confront persistent domestic problems, and failure to achieve life’s goals were the triggering factors in a middle aged female, to compel her to suicide with the help of alprazolam, which was available to her as prescribed by a physician for her ailment.
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References
APA practice guideline for the treatment of patients with panic disorder. 2009. Available at: http:// psychiatry online. Org/content.aspx? bookid = 28& sectionid = 1680738# 154999. Accessed Oct 15, 2012.
FDA approved labelling for Xanax revision 08/23/2011. Federal drug administration [online]. Available from: URL: http://www.accessdata. FDA.gov/drugsatfda_docs/appletter/2011/018276s045,021434s007l tr. pdf. Accessed Oct 15, 2012
Mandrioli R, Mercolini L, Raggi MA. Benzodiazepine metabolism: an analytical perspective. Curr. Drug Metab. 2008 Oct; 9(8): 827- 44.
Physicians’ Desk Reference. 48 th ed. Medical Economics Data Production, Montvale, NJ, 1994.
R.C. Baselt, R.H. Cravey. Disposition of Toxic Drugs and Chemicals in Man. 4th ed. Chemical Toxicology Institute, Foster City, CA, 1995.
G.W. Dawson, S.G. Jue, R.N. Brogden. Alprazolam. A review of its pharmacodynamic properties and efficacy in the treatment of anxiety and depression. Drugs 27: 132-47(1984)
L.E. Edinboro, R.C. Backer. Preliminary report on the application of a high performance liquid chromatographic method for alprazolam in postmortem blood specimens. J. Anal. Toxicol. 9: 207- 208(1985).
D.T. Stafford, A.M. Phillips, G.S. Fernandez, H.S. Nichols. Xanax (alprazolam) - An overdose death. Abstract. American academy of Forensic Sciences Annual Meeting, Anaheim, CA, February 23, 1984.
